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Specific studies to test the action with the drug on parturition, lactation, and improvement in the animal neonate weren't performed, but a general preliminary research in rats indicated no effect on these parameters.

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In animal reproduction experiments, codeine administered with the oral path to Expecting rats during the period of organogenesis enhanced resorptions and lowered fetal weights at a dose around 25 moments the maximum proposed human dose (MRHD) inside the presence of maternal toxicity (see Information).

The MHRA has also been given three case experiences describing addiction especially with codeine linctus.

Usually do not just take promethazine/codeine unless it's been prescribed for you by a Health care provider. Choose it as prescribed.

Codeine Within an embryofetal improvement review in Expecting rats dosed through the entire duration of organogenesis, codeine increased resorptions and reduced fetal weights in a dose approximately 25 instances the MRHD (over a mg/m2 foundation with a maternal oral dose of 120 mg/kg/day); even so, these consequences occurred inside the presence of maternal toxicity.

The result of promethazine and/or codeine on afterwards growth and progress on the new child is unknown.

Opioid analgesics and antitussives, together with codeine, one of many active ingredients in Promethazine HCl and Codeine Phosphate Oral Alternative, really should not be Employed in individuals with acute febrile sickness linked with successful cough or in people with Serious respiratory condition wherever interference with capacity to clear the tracheobronchial tree of secretions would have a deleterious impact on the affected person’s respiratory function.

Circumstances OF USE: The information Within this databases is intended to health supplement, not substitute for, the experience and judgment of Health care specialists. The information is just not intended to check here deal with all doable takes advantage of, directions, safety measures, drug interactions or adverse outcomes, nor really should it be construed to indicate that use of a particular drug is Risk-free, suitable or productive in your case or anybody else.

Codeine is among the naturally transpiring phenanthrene alkaloids of opium derived from the opium poppy; it Akorn Promethazine with codeine syrup is assessed pharmacologically as a narcotic analgesic.

Administration of codeine could possibly be accompanied by histamine release and will be utilized with caution in atopic small children.

Inform your medical professional if you are pregnant or Believe you may well be pregnant. In the course of pregnancy, this merchandise is not advised. It might damage an here unborn toddler. Speak to your doctor with regard to the click here threats and great things about this medication. See also Warning section.

The diagnostic evaluation of sufferers with this syndrome is difficult. In arriving in a analysis, it is crucial to determine situations where by the scientific presentation features both of those really serious professional medical illness (e.

Will not enhance your dose or use this product additional generally or for longer than directed. Your situation will not boost any more quickly, along with here your danger of Negative effects will boost.